منابع مشابه
EPrints makes its mark
Purpose — To report on the impact and cost/benefit of implementing three EPrints digital repositories at the University of Otago, and to encourage others to follow suit. Design/methodology/approach — Three repositories were successfully implemented at the University of Otago using existing commodity hardware and free open source software. The first pilot repository was implemented within ten da...
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A recently recognized strategy for gene regulation involves transcription of a non-coding RNA (ncRNA) transcript that overlaps the gene targeted for regulation. In many cases, it seems that it is the act of transcription itself rather than the ncRNA transcript that mediates regulation. A paper in this issue of the EMBO Journal shows one mechanism by which these transcription events regulate tra...
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How long organisms live is not entirely written in their genes. Recent findings reveal that epigenetic factors that regulate histone methylation, a type of chromatin modification, can affect lifespan. The reversible nature of chromatin modifications suggests that therapeutic targeting of chromatin regulators could be used to extend lifespan and healthspan. This review describes the epigenetic r...
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Genomic imprinting results in the preferential expression of alleles from either the maternal or paternal chromosomes. This epigenetic process occurs in embryonic and extra-embryonic (placental) tissues of mammals, but only in the extra-embryonic tissue (the endosperm) of flowering plant seeds. It is thought that imprinting arose to ensure that both maternal and paternal genomes contribute to t...
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ژورنال
عنوان ژورنال: Nature
سال: 2010
ISSN: 0028-0836,1476-4687
DOI: 10.1038/467646a